SKOV3_OVARY


Available Data

  • Vendor Karyotype
  • ecDNA Presence Verification from Literature
  • Amplicon Architect Prediction
  • Circle Hunter Prediction

ID Value
ATCC HTB-77
DSMZ None
Cellosaurus SK-OV-3
Cosmic 905959.0

Property Value
% Polyploidy 32.0
Ploidy Classification hypodiploid
Modal Chromosome Number 43.0
Modal Range Numeric 42-45
Marker Chromosomes Average Field 7.0
Primary or Metastasis Metastasis
Count of SV's 4

Details

ecDNA Present (Y/N/P): Y

Literature source: https://www.nature.com/articles/nature21356

HSR Classification: Y

ATCC Karyotype: This is a hypodiploid human cell line. The modal chromosome number was 43, occurring in 63.3% of cells. The range was 42 to 45. The rate of higher ploidies was 32%. The del(1)(q21), der(13)t(1;?;13) (q11;?;q34), der(11)t(11;?) (q12), del(10)(q22) and 3 other marker chromosomes were common to most cells, and 3 others were found only in some cells. One N11 had the HSR segment from p11 to the distal end. The normal N10, N12, N15, N17 and N19 were absent. Others were either single or paired. There were from 1 to 6 rearranged and unassignable chromosomes. The X chromosome was either single or paired.

DSMZ Karyotype: No data

Heterogeneity Indications and Other Notes: One N11 had the HSR segment from p11 to the distal end

Download Breakpoint Edges CSV

Prediction

ecDNA Amplicon Predicted: Y

Predicted Amplicon Classes: ['ecDNA']

Predicted Genes on ecDNA

['CDK12', 'ERBB2', 'MECOM', 'MIEN1', 'NEUROD2', 'PGAP3', 'PNMT', 'PPP1R1B', 'PSEN1', 'STARD3', 'TCAP', 'TRPC7', 'CASC19', 'CASC21', 'CASC8', 'CCAT1', 'HAPLN4', 'SUGP1', 'TM6SF2']

Predicted Features

Class Amplicon Complexity Score
ecDNA 1 0.6289172569
Image 1

Class Amplicon Complexity Score
ecDNA 2 1.520703045
Image 2

Class Amplicon Complexity Score
ecDNA 3 0.6547074826
Image 3

Class Amplicon Complexity Score
ecDNA 4 0.6862734143
Image 4

Prediction

ecDNA: positive

Genes: .


Prediction

No data