SKMES1_LUNG


Available Data

  • Vendor Karyotype
  • Amplicon Architect Prediction
  • Shatterseek Prediction

ID Value
ATCC HTB-58
DSMZ ACC-353
Cellosaurus SK-MES-1
Cosmic 909728.0

Property Value
% Polyploidy 44.0
Ploidy Classification mix (hypotriploid, hyperdiploid)
Modal Chromosome Number None
Modal Range Numeric 54-60
Marker Chromosomes Average Field 20.0
Primary or Metastasis Metastasis
Count of SV's 18

Details

ecDNA Present (Y/N/P): N

HSR Classification: N

ATCC Karyotype: The stemline chromosome number is hypotriploid, with the 2S component occurring at 3.2%. Seventeen to 20 marker chromosomes were common to most S metaphases. Normal X, 13, and 19 chromosomes were absent, and chromosomes 2, 3, 14, 17 and 20 were generally monosomic. The Y chromosome was not detected using QM staining.

DSMZ Karyotype: human flat-moded hyperdiploid karyotype with 44% polyploidy - 54-60<2n>X, -Y, +1, +1, -2, +4, +5, +7, +7, +11, +13, +19, +22, +5mar, add(X)(p21), i(1q), del(1)(q12)x1-2, add(2)(q37), del(3)(p22p26), add(4)(q32), der(5)t(5;6)(p15;p11), del(5)(q13), add(7)(q11;abr), add(11)(q2)x2, add(13)(p12)x1-2, add(13)(p12), add(15)(p12), der(16)t(8;16)(q12;q23), del(17)(p11), add(19)(p13)x2-3 - sideline with additional der(7;8)(q10;p10), add(22)(q13), der(11)dup(11)(q13q22) - carries 3p-, 5q-, +7, 17p- associated with NSCLC - matches published karyotype

Heterogeneity Indications and Other Notes: No data

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Prediction

ecDNA Amplicon Predicted: Y

Predicted Amplicon Classes: ['Linear amplification', 'ecDNA', 'Complex non-cyclic']

Predicted Genes on ecDNA

[]

Predicted Features

Class Amplicon Complexity Score
Linear amplification 1 0.6929152139
Image 1

Class Amplicon Complexity Score
ecDNA 3 0.5398683613
Image 2

Class Amplicon Complexity Score
Complex non-cyclic 5 0.956816222
Image 3

Prediction

ecDNA: None


Prediction

Shatterseek Prediction: High Confidence

Shatterseek High Confidence Chromosomes: 2, 4

Shatterseek Low Confidence Chromosomes: 5, 6