SKMEL5_SKIN


Available Data

  • Vendor Karyotype
  • ecDNA Presence Verification from Literature
  • Amplicon Architect Prediction
  • Shatterseek Prediction

ID Value
ATCC HTB-70
DSMZ None
Cellosaurus SK-MEL-5
Cosmic 905956.0

Property Value
% Polyploidy None
Ploidy Classification hyperpentaploid
Modal Chromosome Number 120.0
Modal Range Numeric 95-133
Marker Chromosomes Average Field 14.0
Primary or Metastasis Metastasis
Count of SV's 5

Details

ecDNA Present (Y/N/P): N

Literature source: https://www.nature.com/articles/nature21356

HSR Classification: N

ATCC Karyotype: modal number = 120; range = 95 to 133.This is a hyperpentaploid human cell line with the modal chromosome number of 120, occurring in 9% of cells. The majority of cells had chromosome counts of 114-123. Among 14 marker chromosomes that were common to most cells, generally 9q+ had four copies per cell, t(1q8q) and del(5) (q34) had three copies per cell, and 14q+ had two copies per cell. Numerous others were also found in single copies, all infrequently. Three normal X chromosomes were found in most cells, N9 was absent, and N7 and N20 had seven to eight copies per cell.

DSMZ Karyotype: No data

Heterogeneity Indications and Other Notes: No data

Download Breakpoint Edges CSV

Prediction

ecDNA Amplicon Predicted: Y

Predicted Amplicon Classes: ['ecDNA', 'Linear amplification']

Predicted Genes on ecDNA

['ANO1', 'CCND1', 'CTTN', 'FADD', 'FGF19', 'FGF3', 'FGF4', 'LTO1', 'MYEOV', 'PPFIA1', 'SHANK2', 'SHANK2-AS1', 'SMIM38', 'TPCN2']

Predicted Features

Class Amplicon Complexity Score
ecDNA 1 0.4718314158
Image 1

Class Amplicon Complexity Score
Linear amplification 2 0.9790227777
Image 2

Prediction

ecDNA: None


Prediction

Shatterseek Prediction: No Chromothripsis Detected

Shatterseek High Confidence Chromosomes: None

Shatterseek Low Confidence Chromosomes: None