Available Data

Vendor Karyotype
ecDNA Presence Verification from Literature
Amplicon Architect Prediction

ID	Value
ATCC	HTB-161
DSMZ	None
Cellosaurus	OVCAR-3
Cosmic	905933.0

Karyotype Details

Property	Value
% Polyploidy	None
Ploidy Classification	mix(hypotriploid, triploid)
Modal Chromosome Number	None
Modal Range Numeric	58-71
Marker Chromosomes Average Field	None
Primary or Metastasis	Metastasis
Count of SV's	0

Details

ecDNA Present (Y/N/P): N

Literature source: https://pubmed.ncbi.nlm.nih.gov/6604576/
https://www.nature.com/articles/nature21356

HSR Classification: Y

ATCC Karyotype: The cell line is aneuploid human female, with chromosome counts in the sub to near-triploid range. Several normal chromosomes (N11, N13, N14, N15, N16, N17, and N22) are clearly under-represented. Many of these missing chromosomes are represented in the large number of cytogenetically altered chromosomes identified as marker chromosomes. In addition to the marker chromosomes, there are a large number of other structurally abnormal and unassignable chromosomes that are not recognized as markers. Random loss and gain of chromosomes from cell to cell are noted in the exact chromosome counts and in the analysis of the karyotypes.

DSMZ Karyotype: No data

Heterogeneity Indications and Other Notes: Neither DM nor HSR were detected (ATCC)

Download Breakpoint Edges CSV

Prediction

ecDNA Amplicon Predicted: Y

Predicted Amplicon Classes: ['Linear amplification', 'ecDNA', 'BFB']

Predicted Genes on ecDNA

['MORF4L2', 'MORF4L2-AS1', 'TCEAL1', 'TCEAL3', 'C19orf12', 'CCNE1', 'PLEKHF1', 'POP4', 'URI1', 'VSTM2B', 'ARHGEF17', 'ATG16L2', 'FAM168A', 'FCHSD2', 'P2RY2', 'P2RY6', 'RELT', 'STARD10', 'AKT2', 'BLVRB', 'C19orf47', 'CLC', 'CNTD2', 'DLL3', 'DYRK1B', 'EID2', 'EID2B', 'FBL', 'FCGBP', 'GMFG', 'HIPK4', 'LEUTX', 'LGALS13', 'LGALS14', 'LGALS16', 'LGALS17A', 'LRFN1', 'MAP3K10', 'MED29', 'PAF1', 'PLD3', 'PLEKHG2', 'PRX', 'PSMC4', 'RPS16', 'SAMD4B', 'SELENOV', 'SERTAD1', 'SERTAD3', 'SNORD175', 'SUPT5H', 'TIMM50', 'TTC9B', 'ZFP36', 'ZNF546', 'ZNF780A', 'ZNF780B']

Predicted Features

View Feature 1 - NIHOVCAR3_OVARY Linear amplification

Class	Amplicon	Complexity Score
Linear amplification	11	0.3228122506

View Feature 2 - NIHOVCAR3_OVARY ecDNA

Class	Amplicon	Complexity Score
ecDNA	12	0.6911254791

View Feature 3 - NIHOVCAR3_OVARY Linear amplification

Class	Amplicon	Complexity Score
Linear amplification	1	0.5713026279

View Feature 4 - NIHOVCAR3_OVARY Linear amplification

Class	Amplicon	Complexity Score
Linear amplification	2	0.6495692559

View Feature 5 - NIHOVCAR3_OVARY ecDNA

Class	Amplicon	Complexity Score
ecDNA	3	0.9928172547

View Feature 6 - NIHOVCAR3_OVARY Linear amplification

Class	Amplicon	Complexity Score
Linear amplification	4	1.208179972

View Feature 7 - NIHOVCAR3_OVARY Linear amplification

Class	Amplicon	Complexity Score
Linear amplification	5	0.5666302665

View Feature 8 - NIHOVCAR3_OVARY ecDNA

Class	Amplicon	Complexity Score
ecDNA	6	0.8577023856

View Feature 9 - NIHOVCAR3_OVARY BFB

Class	Amplicon	Complexity Score
BFB	7	1.164847462

View Feature 10 - NIHOVCAR3_OVARY Linear amplification

Class	Amplicon	Complexity Score
Linear amplification	8	0.8469288025

View Feature 11 - NIHOVCAR3_OVARY ecDNA

Class	Amplicon	Complexity Score
ecDNA	9	0.5220807027

View Feature 12 - NIHOVCAR3_OVARY ecDNA

Class	Amplicon	Complexity Score
ecDNA	9	0.6714764423

Prediction

ecDNA: None

Prediction

No data