NCIH69_LUNG


Available Data

  • Vendor Karyotype
  • ecDNA Presence Verification from Literature
  • Amplicon Architect Prediction

ID Value
ATCC HTB-119
DSMZ None
Cellosaurus NCI-H69
Cosmic 688027.0

Property Value
% Polyploidy None
Ploidy Classification hypertriploid
Modal Chromosome Number 77.0
Modal Range Numeric 40-87
Marker Chromosomes Average Field 12.0
Primary or Metastasis Metastasis
Count of SV's 5

Details

ecDNA Present (Y/N/P): Y

Literature source: https://aacrjournals.org/cancerdiscovery/article/13/4/928/725029/Extrachromosomal-DNA-Amplification-Contributes-to

HSR Classification: N

ATCC Karyotype: modal number = 76 to 78; range = 40 to 87This is an aneuploid human male cell line. Monosomy of many of the normal chromosomes is noted as well as bisomy in this subtetraploid cell line; however, translocations and deletions involving many of the missing chromosomes are noted, and these chromosomal rearrangements appear to be stable and generally paired. Twelve marker chromosomes were identified including: der(16)t(1;16)(q21;q23), der(22)t(4;22)(q12;q13), der(12)t(11;12)(q23;p12), del(17)(p11), der(19)t(5;19)(?q21;q13) and others.

DSMZ Karyotype: No data

Heterogeneity Indications and Other Notes: No data

Download Breakpoint Edges CSV

Prediction

ecDNA Amplicon Predicted: Y

Predicted Amplicon Classes: ['ecDNA']

Predicted Genes on ecDNA

['ASB3', 'GPR75-ASB3', 'LRRTM4-AS1', 'MYCN', 'MYCNOS', 'MYCNUT', 'AMN1', 'BICD1', 'CAPRIN2', 'DDX11', 'DDX11-AS1', 'DENND5B', 'DENND5B-AS1', 'ETFBKMT', 'FGD4', 'FLJ13224', 'H3-5', 'IPO8', 'OVOS2', 'RESF1', 'SINHCAF', 'TSPAN11']

Predicted Features

Class Amplicon Complexity Score
ecDNA 1 1.060499427
Image 1

Class Amplicon Complexity Score
ecDNA 2 0.6924720945
Image 2

Prediction

ecDNA: None


Prediction

No data