NCIH520_LUNG


Available Data

  • Vendor Karyotype
  • Amplicon Architect Prediction
  • Shatterseek Prediction

ID Value
ATCC HTB-182
DSMZ None
Cellosaurus NCI-H520
Cosmic 908443.0

Property Value
% Polyploidy 3.2
Ploidy Classification hypotriploid
Modal Chromosome Number 58.0
Modal Range Numeric 58-68
Marker Chromosomes Average Field 30.0
Primary or Metastasis Primary
Count of SV's 5

Details

ecDNA Present (Y/N/P): N

HSR Classification: N

ATCC Karyotype: This is a hypotriploid human cell line. The modal chromosome number is 58 occurring at 30%. The frequency of higher ploidies was 3.2%. Over 30 marker chromosomes were common to all cells, and four others were found in some cells. Among the common markers were 1q+, t(1q8q), 2q+, der(16)t(3;16)(q21;q22), der(19)t(13;19)(q21;q13), and der(5)t(5;5)(p15pq13). Generally, there were two copies of der(5) in each cell. Normal Y and D group chromosomes were absent, and the X chromosome was single.

DSMZ Karyotype: No data

Heterogeneity Indications and Other Notes: 5p+(HSR)

Download Breakpoint Edges CSV

Prediction

ecDNA Amplicon Predicted: Y

Predicted Amplicon Classes: ['ecDNA', 'Linear amplification', 'BFB']

Predicted Genes on ecDNA

['AKIRIN1', 'BMP8A', 'BMP8B', 'CAP1', 'COL9A2', 'GJA9', 'GJA9-MYCBP', 'HEYL', 'HPCAL4', 'KIAA0754', 'MACF1', 'MFSD2A', 'MYCBP', 'MYCL', 'NDUFS5', 'NT5C1A', 'OXCT2', 'OXCT2P1', 'PABPC4', 'PABPC4-AS1', 'PPIE', 'PPIEL', 'PPT1', 'RHBDL2', 'RLF', 'RRAGC', 'SMAP2', 'SNORA55', 'TMCO2', 'TRIT1', 'ZMPSTE24', 'NPFFR2', 'FAM13A', 'FAM13A-AS1', 'HERC3', 'NAP1L5']

Predicted Features

Class Amplicon Complexity Score
ecDNA 1 0.658120194
Image 1

Class Amplicon Complexity Score
ecDNA 1 0.673873857
Image 2

Class Amplicon Complexity Score
Linear amplification 2 0.6247096681
Image 3

Class Amplicon Complexity Score
BFB 3 0.702598796
Image 4

Class Amplicon Complexity Score
BFB 4 1.528508921
Image 5

Class Amplicon Complexity Score
ecDNA 5 0.6417996196
Image 6

Class Amplicon Complexity Score
Linear amplification 6 0.3945728567
Image 7

Class Amplicon Complexity Score
Linear amplification 7 0.6797630115
Image 8

Class Amplicon Complexity Score
Linear amplification 8 0.0
Image 9

Prediction

ecDNA: None


Prediction

Shatterseek Prediction: High Confidence

Shatterseek High Confidence Chromosomes: 11

Shatterseek Low Confidence Chromosomes: 4, 6, 7, 10, 12, 19