NCIH1963_LUNG


Available Data

  • Vendor Karyotype
  • ecDNA Presence Verification from Literature
  • Amplicon Architect Prediction
  • Circle Hunter Prediction
  • Shatterseek Prediction

ID Value
ATCC CRL-5982
DSMZ ACC-540
Cellosaurus NCI-H1963
Cosmic 688010.0

Property Value
% Polyploidy 3.0
Ploidy Classification mix(hypodiploid, hypotetraploid)
Modal Chromosome Number 44.0
Modal Range Numeric 42-48
Marker Chromosomes Average Field 2.0
Primary or Metastasis Primary
Count of SV's 8

Details

ecDNA Present (Y/N/P): Y

Literature source: https://aacrjournals.org/cancerdiscovery/article/13/4/928/725029/Extrachromosomal-DNA-Amplification-Contributes-to

HSR Classification: Y

ATCC Karyotype: 3p is normal

DSMZ Karyotype: human bimodal hypodiploid/hypotetraploid aryotype with 3% polyploidy - 44(42-48)<2n>X, -Y, -5, -10, -13, +18, -19, +2mar, add(1)(q32), ins(2;hsr)(p21-23;?), add(3)(p11), del(4)(q24-26), del(10)(p13-14), add(18)(p11)x2, del(20)(q12), der(22)(t1;22)(q12;q13), dmin present in some cells

Heterogeneity Indications and Other Notes: No data

Download Breakpoint Edges CSV

Prediction

ecDNA Amplicon Predicted: Y

Predicted Amplicon Classes: ['ecDNA']

Predicted Genes on ecDNA

['BMP8B', 'CAP1', 'COL9A2', 'EXO5', 'HPCAL4', 'MFSD2A', 'MYCL', 'NT5C1A', 'OXCT2', 'PPIE', 'PPT1', 'RIMS3', 'RLF', 'SMAP2', 'TMCO2', 'TRIT1', 'ZFP69', 'ZFP69B', 'ZMPSTE24', 'ZNF684']

Predicted Features

Class Amplicon Complexity Score
ecDNA 1 1.212967667
Image 1

Class Amplicon Complexity Score
ecDNA 2 0.6780096604
Image 2

Prediction

ecDNA: negative


Prediction

Shatterseek Prediction: Low Confidence

Shatterseek High Confidence Chromosomes: None

Shatterseek Low Confidence Chromosomes: X