Available Data

Vendor Karyotype
Amplicon Architect Prediction
Circle Hunter Prediction

ID	Value
ATCC	HTB-132
DSMZ	ACC-738
Cellosaurus	MDA-MB-468
Cosmic	908123.0

Karyotype Details

Property	Value
% Polyploidy	None
Ploidy Classification	hypotriploid
Modal Chromosome Number	64.0
Modal Range Numeric	60-67
Marker Chromosomes Average Field	None
Primary or Metastasis	Metastasis
Count of SV's	0

Details

ecDNA Present (Y/N/P): N

HSR Classification: N

ATCC Karyotype: modal number = 64; range = 60 to 67.The cell line is aneuploid human, presumably female (X, abnormal X) with most chromosome counts in the hypotriploid range.; Normal chromosomes X, N2, N3, N7, N8, N10, and N22 are clearly under-represented due to their involvement in the formation of the many marker (19) chromosomes present in this cell line.; A normal chromosome N1 (or two) is identified in each karyotype, but, in addition, regions of chromosome N1 are also present in five different marker chromosomes.; Variation is evident in the normal and marker chromosome copy number from karyotype to karyotype.

DSMZ Karyotype: No data

Heterogeneity Indications and Other Notes: No data

Download Breakpoint Edges CSV

Prediction

ecDNA Amplicon Predicted: Y

Predicted Amplicon Classes: ['BFB', 'ecDNA', 'Linear amplification', 'Complex non-cyclic']

Predicted Genes on ecDNA

['ALDH1B1', 'ARHGEF39', 'ATP8B5P', 'C9orf131', 'CA9', 'CCDC107', 'CCIN', 'CD72', 'CLTA', 'CREB3', 'DCAF10', 'DNAJB5', 'DNAJB5-DT', 'EBLN3P', 'EXOSC3', 'FAM166B', 'FAM214B', 'FAM221B', 'FANCG', 'FBXO10', 'FRMPD1', 'GBA2', 'GLIPR2', 'GNE', 'GRHPR', 'HINT2', 'HRCT1', 'IGFBPL1', 'MELK', 'MSMP', 'NPR2', 'OR13J1', 'OR2S2', 'PAX5', 'PHF24', 'PIGO', 'POLR1E', 'RECK', 'RGP1', 'RMRP', 'RNF38', 'RUSC2', 'SHB', 'SIT1', 'SLC25A51', 'SPAAR', 'SPAG8', 'STOML2', 'TESK1', 'TLN1', 'TMEM8B', 'TOMM5', 'TPM2', 'TRMT10B', 'UNC13B', 'VCP', 'ZBTB5', 'ZCCHC7', 'SOX9', 'SOX9-AS1']

Predicted Features

View Feature 1 - MDAMB468_BREAST ecDNA

Class	Amplicon	Complexity Score
ecDNA	1	0.593800744

View Feature 2 - MDAMB468_BREAST BFB

Class	Amplicon	Complexity Score
BFB	1	1.185317184

View Feature 3 - MDAMB468_BREAST ecDNA

Class	Amplicon	Complexity Score
ecDNA	2	0.5087278428

View Feature 4 - MDAMB468_BREAST Linear amplification

Class	Amplicon	Complexity Score
Linear amplification	3	1.41013518

View Feature 5 - MDAMB468_BREAST Complex non-cyclic

Class	Amplicon	Complexity Score
Complex non-cyclic	4	1.882906081

View Feature 6 - MDAMB468_BREAST ecDNA

Class	Amplicon	Complexity Score
ecDNA	5	0.6396121607

View Feature 7 - MDAMB468_BREAST BFB

Class	Amplicon	Complexity Score
BFB	6	0.9164083762

Prediction

ecDNA: positive

Genes: .

Prediction

No data