MDAMB453_BREAST


Available Data

  • Vendor Karyotype
  • Amplicon Architect Prediction

ID Value
ATCC HTB-131
DSMZ ACC-65
Cellosaurus MDA-MB-453
Cosmic 908122.0

Property Value
% Polyploidy 6.0
Ploidy Classification hypotetraploid
Modal Chromosome Number 89.0
Modal Range Numeric 85-91
Marker Chromosomes Average Field None
Primary or Metastasis Metastasis
Count of SV's 1

Details

ecDNA Present (Y/N/P): Y

HSR Classification: N

ATCC Karyotype: modal number = 90; range = 87 to 91.The cell line is aneuploid human female, with chromosome counts in the hypo- to near-tetraploid range. Normal chromosomes N11, N13, and N17 are absent, and chromosomes N2, N6, and N12 are clearly under-represented with respect to the copy number of other normal chromosomes, while chromosome N20 tends towards over-representation. A large number of marker chromosomes are present with consistency, many of them with more than one copy. The near-diploid population of cells reported for this culture has been replaced by a tetraploid population.

DSMZ Karyotype: human hypotetraploid karyotype with 6% polyploidy and near diploid sideline (2%) - 89(85-91)<4n>XXX, -X - highly rearranged leading to extensive marker formation, including der(5)t(5;?14)(p11;q11)x2 - dm present in 12% cells

Heterogeneity Indications and Other Notes: dm present in 12% cells

Download Breakpoint Edges CSV

Prediction

ecDNA Amplicon Predicted: Y

Predicted Amplicon Classes: ['Complex non-cyclic', 'BFB', 'Linear amplification', 'ecDNA']

Predicted Genes on ecDNA

['ATP6AP1', 'BRCC3', 'CH17-340M24.3', 'CLIC2', 'CMC4', 'CTAG1A', 'CTAG1B', 'CTAG2', 'DKC1', 'DNASE1L1', 'EMD', 'F8', 'F8A1', 'F8A2', 'F8A3', 'FAM223A', 'FAM223B', 'FAM3A', 'FAM50A', 'FLNA', 'FUNDC2', 'G6PD', 'GAB3', 'GDI1', 'H2AB1', 'H2AB2', 'H2AB3', 'IKBKG', 'LAGE3', 'MECP2', 'MPP1', 'MTCP1', 'OPN1LW', 'OPN1MW', 'OPN1MW2', 'OPN1MW3', 'PLXNA3', 'RAB39B', 'RPL10', 'SLC10A3', 'SMIM9', 'SNORA36A', 'SNORA56', 'SNORA70', 'TAZ', 'TEX28', 'TKTL1', 'TMLHE', 'TMLHE-AS1', 'UBL4A', 'VBP1']

Predicted Features

Class Amplicon Complexity Score
Complex non-cyclic 1 0.9686044595
Image 1

Class Amplicon Complexity Score
BFB 2 1.056177983
Image 2

Class Amplicon Complexity Score
Complex non-cyclic 3 1.412049712
Image 3

Class Amplicon Complexity Score
Complex non-cyclic 4 1.931727508
Image 4

Class Amplicon Complexity Score
Linear amplification 5 0.6490891751
Image 5

Class Amplicon Complexity Score
Linear amplification 6 1.168063673
Image 6

Class Amplicon Complexity Score
ecDNA 7 0.673539345
Image 7

Prediction

ecDNA: None


Prediction

No data