Available Data

Vendor Karyotype
ecDNA Presence Verification from Literature
Amplicon Architect Prediction

ID	Value
ATCC	HTB-129
DSMZ	None
Cellosaurus	MDA-MB-435S
Cosmic	None

Karyotype Details

Property	Value
% Polyploidy	None
Ploidy Classification	hyperdiploid
Modal Chromosome Number	56.0
Modal Range Numeric	55-62
Marker Chromosomes Average Field	19.0
Primary or Metastasis	Metastasis
Count of SV's	6

Details

ecDNA Present (Y/N/P): Y

Literature source: https://www.nature.com/articles/nature21356

HSR Classification: N

ATCC Karyotype: modal number = 56; range = 55 to 62The cell line is aneuploid human female (XX), with most chromosome counts in the 55 to 60 range. Normal chromosomes N6, N11, and N22 were absent, while chromosomes N7, N13, N18 and N21 were single. Most of the remainder of normal chromosomes were usually paired, but chromosome N2 was triple. Nineteen marker chromosomes were identified, with most of them formed from structural alterations of the missing copies of the normal chromosomes. Six of these markers involve regions of chromosome N7, while three are recognized as derivatives of chromosome N6. Regions of a third copy of the normal and paired chromosomes N3, N15, N17, N20 are noted in markers M1, M2, M15, and M5, respectively.

DSMZ Karyotype: No data

Heterogeneity Indications and Other Notes: No data

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