Available Data

Vendor Karyotype
Amplicon Architect Prediction
Shatterseek Prediction

ID	Value
ATCC	HTB-25
DSMZ	None
Cellosaurus	MDA-MB-175-VII
Cosmic	908120.0

Karyotype Details

Property	Value
% Polyploidy	None
Ploidy Classification	hypotetraploid
Modal Chromosome Number	84.0
Modal Range Numeric	82-89
Marker Chromosomes Average Field	5.0
Primary or Metastasis	Metastasis
Count of SV's	3

Details

ecDNA Present (Y/N/P): N

HSR Classification: N

ATCC Karyotype: model number = 84; range = 82 to 89. The cell line is aneuploid female (XX/XXX/XXXX), with chromosome counts in the hypertetraploid to near-tetraploid range. All normal chromosomes are represented by at least one copy, with most chromosomes having three or four copies present per karyotype. Five marker chromosomes are found: del(1)p35), der(7)t(1;7)(q11;q32), unknown, t(2q;?), unknown isochromosome. Several are present in multiple copy. Alterations in the q arm of chromosome N1 are in accordance with the report by M.J. Siciliano, et al., Cancer Res. 39: 919, 1979.

DSMZ Karyotype: No data

Heterogeneity Indications and Other Notes: No data

Download Breakpoint Edges CSV

Prediction

ecDNA Amplicon Predicted: Y

Predicted Amplicon Classes: ['BFB', 'ecDNA', 'Linear amplification']

Predicted Genes on ecDNA

['ANO1', 'CCND1', 'CPT1A', 'CTTN', 'FADD', 'FGF19', 'FGF3', 'FGF4', 'GAL', 'IGHMBP2', 'LRP5', 'LTO1', 'MRGPRD', 'MRGPRF', 'MRGPRF-AS1', 'MRPL21', 'MYEOV', 'PPFIA1', 'PPP6R3', 'SHANK2', 'SMIM38', 'TESMIN', 'TPCN2', 'AAMDC', 'ACER3', 'ALG8', 'AQP11', 'ARRB1', 'B3GNT6', 'CAPN5', 'CHRDL2', 'CLNS1A', 'DGAT2', 'EMSY', 'GAB2', 'GDPD4', 'GDPD5', 'GUCY2EP', 'GVQW3', 'INTS4', 'KCNE3', 'KCTD14', 'KCTD21', 'KCTD21-AS1', 'KLHL35', 'LIPT2', 'LRRC32', 'MAP6', 'MOGAT2', 'MYO7A', 'NARS2', 'NDUFC2', 'NDUFC2-KCTD14', 'OMP', 'PAK1', 'POLD3', 'RNF169', 'RPS3', 'RSF1', 'SERPINH1', 'SLCO2B1', 'SNORD15A', 'SNORD15B', 'SPCS2', 'TENM4', 'THAP12', 'THRSP', 'TPBGL', 'TSKU', 'USP35', 'UVRAG', 'UVRAG-DT', 'WNT11', 'XRRA1']

Predicted Features

View Feature 1 - MDAMB175VII_BREAST BFB

Class	Amplicon	Complexity Score
BFB	1	0.9418747114

View Feature 2 - MDAMB175VII_BREAST ecDNA

Class	Amplicon	Complexity Score
ecDNA	2	0.7340891273

View Feature 3 - MDAMB175VII_BREAST ecDNA

Class	Amplicon	Complexity Score
ecDNA	2	0.7348324043

View Feature 4 - MDAMB175VII_BREAST Linear amplification

Class	Amplicon	Complexity Score
Linear amplification	3	0.5635110447

Prediction

ecDNA: None

Prediction

Shatterseek Prediction: Low Confidence

Shatterseek High Confidence Chromosomes: None

Shatterseek Low Confidence Chromosomes: 11, 19