HS746T_STOMACH


Available Data

  • Vendor Karyotype
  • Amplicon Architect Prediction
  • Shatterseek Prediction

ID Value
ATCC HTB-135
DSMZ None
Cellosaurus Hs 746.T
Cosmic 1240151.0

Property Value
% Polyploidy 16.6
Ploidy Classification hypertriploid
Modal Chromosome Number 77.0
Modal Range Numeric 70-80
Marker Chromosomes Average Field 10.0
Primary or Metastasis Metastasis
Count of SV's 6

Details

ecDNA Present (Y/N/P): Y

HSR Classification: N

ATCC Karyotype: This is a hypertriploid human cell line having the modal chromosome number of 77 occurring in 46% of cells. Cells with higher ploidies were found at 16.6%. The karyotype of this cell line is very complex. Between 45% and 55% of chromosomes in each cell had structural aberrations, including: der(4)t(1;4) (p13.1;q35); t(15q22q); del(2) (p13); der(7)t(7;?) (p22;?) [7p+]; t(7q22q?) and others. The t(15q22q), del(2), and t(7q22q?) (and several others) had two copies in most cells. There were two types of der(7): one was the 7p+ described above; the other, 7p++, was distinctly longer than N1. There were more than ten markers that were present in some cells only. One DM-like chromosome was found in most cells. Normal N7 and N21 were absent. One normal X and one or two normal Y chromosomes were detected.

DSMZ Karyotype: No data

Heterogeneity Indications and Other Notes: No data

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Prediction

ecDNA Amplicon Predicted: Y

Predicted Amplicon Classes: ['Complex non-cyclic', 'ecDNA', 'Linear amplification']

Predicted Genes on ecDNA

['ASPN', 'ASZ1', 'AUH', 'C12orf73', 'CAPZA2', 'CAV1', 'CAV2', 'CENPP', 'CFTR', 'CFTR-AS1', 'CHST11', 'ECM2', 'EID3', 'GLT8D2', 'HCFC2', 'HSP90B1', 'IARS1', 'IPPK', 'MET', 'NFIL3', 'NFYB', 'NOL8', 'NT5DC3', 'OGN', 'OMD', 'PRSS47', 'ROR2', 'SNORA84', 'SPTLC1', 'ST7', 'ST7-AS1', 'ST7-AS2', 'ST7-OT3', 'ST7-OT4', 'SYK', 'TDG', 'TES', 'TFEC', 'TTC41P', 'TXNRD1', 'WNT2', 'BCAP29', 'CBLL1', 'CCDC71L', 'COG5', 'DUS4L', 'DUS4L-BCAP29', 'GPR22', 'HBP1', 'PIK3CG', 'PRKAR2B', 'SLC26A3', 'SLC26A4', 'SLC26A4-AS1']

Predicted Features

Class Amplicon Complexity Score
Complex non-cyclic 1 0.7264477386
Image 1

Class Amplicon Complexity Score
ecDNA 2 1.445403672
Image 2

Class Amplicon Complexity Score
Linear amplification 3 0.8905879697
Image 3

Class Amplicon Complexity Score
ecDNA 4 0.5513337827
Image 4

Class Amplicon Complexity Score
Linear amplification 5 0.723957937
Image 5

Prediction

ecDNA: None


Prediction

Shatterseek Prediction: Low Confidence

Shatterseek High Confidence Chromosomes: None

Shatterseek Low Confidence Chromosomes: 7, 10