HCT116_LARGE_INTESTINE


Available Data

  • Vendor Karyotype
  • ecDNA Presence Verification from Literature
  • Amplicon Architect Prediction
  • Circle Hunter Prediction
  • Shatterseek Prediction

ID Value
ATCC CCL-247
DSMZ ACC-581
Cellosaurus HCT 116
Cosmic 905936.0

Property Value
% Polyploidy 3.0
Ploidy Classification hypodiploid
Modal Chromosome Number 45.0
Modal Range Numeric 35-45
Marker Chromosomes Average Field None
Primary or Metastasis Primary
Count of SV's 5

Details

ecDNA Present (Y/N/P): N

Literature source: https://www.nature.com/articles/nature21356

HSR Classification: N

ATCC Karyotype: The stemline chromosome number is near diploid with the modal number at 45 (62%) and polyploids occurring at 6.8%. The markers 10q+ and t(?8p;18q) are present in all metaphases and t(9q;?16p-), in 80% of the cells karyotyped. N16 is monosomic in the presence of, but disomic in the absence of t(9q;?16p-). N10 and N18 are monosomic and other chromosomes from those mentioned above are disomic. Q-band observations revealed the presence of the Y chromosome, but not in all cells (50% of cells lacked the Y in G-band karyotypes).

DSMZ Karyotype: human near-diploid karyotype with 3% polyploidy - 45(44-46)<2n>X/XY, add(10)(q24-26), der(16)t(8;16)(q13;p13), der(18)t(17;18)(q13-21;p11.3) - resembles published karyotypes

Heterogeneity Indications and Other Notes: No data

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Prediction

ecDNA Amplicon Predicted: N

Predicted Amplicon Classes: []

Predicted Genes on ecDNA

[]

Predicted Features

No features detected.


Prediction

ecDNA: positive

Genes: .;AMZ2P2;UBA52P5


Prediction

Shatterseek Prediction: High Confidence

Shatterseek High Confidence Chromosomes: 1, 8

Shatterseek Low Confidence Chromosomes: 15