HCC827_LUNG


Available Data

  • Vendor Karyotype
  • ecDNA Presence Verification from Literature
  • Amplicon Architect Prediction
  • Circle Hunter Prediction

ID Value
ATCC CRL-2868
DSMZ ACC-566
Cellosaurus HCC827
Cosmic 1240146.0

Property Value
% Polyploidy 6.0
Ploidy Classification hypotriploid
Modal Chromosome Number 62.0
Modal Range Numeric 54-66
Marker Chromosomes Average Field 3.0
Primary or Metastasis Primary
Count of SV's 8

Details

ecDNA Present (Y/N/P): N

Literature source: https://www.nature.com/articles/nature21356

HSR Classification: Y

ATCC Karyotype: No data

DSMZ Karyotype: human flat-moded hypotriploid karyotype with 6% polyploidy - 62(54-66)<3n>XXX/XXXX, -1, +7, +7, -9, -10, -15, -17, -18, -21, -22, +3 mar, +0-4 dmin, add(X)(p11), dup(2)(p1?p2?), add(3)(p11), add(6)(p21), add(7)(p12), add(7)(p22), add(7)(q21.2;HSR), add(21)(p11), der(21;22)(q10;q10), add(22)(p11) - 2 large submetacentric HSR markers present

Heterogeneity Indications and Other Notes: No data

Download Breakpoint Edges CSV

Prediction

ecDNA Amplicon Predicted: Y

Predicted Amplicon Classes: ['Complex non-cyclic', 'Linear amplification', 'BFB', 'ecDNA']

Predicted Genes on ecDNA

['EGFR', 'EGFR-AS1', 'SEC61G', 'VSTM2A', 'VSTM2A-OT1', 'ELOC', 'LY96', 'RDH10', 'RDH10-AS1', 'RPL7', 'STAU2', 'STAU2-AS1', 'TMEM70', 'UBE2W', 'ADCY8', 'ARFGEF1', 'ASAP1', 'ASAP1-IT1', 'ASAP1-IT2', 'BTG3', 'BTG3-AS1', 'C21orf91', 'C21orf91-OT1', 'CASC11', 'CASC19', 'CASC21', 'CASC8', 'CCAT1', 'CCAT2', 'CCDC26', 'CHODL', 'CHODL-AS1', 'CPA6', 'CXADR', 'DNAJC5B', 'EFR3A', 'FAM49B', 'GSDMC', 'HHLA1', 'HPYR1', 'KCNQ3', 'KHDRBS3', 'LRATD2', 'LRRC6', 'MYC', 'NCRNA00250', 'OC90', 'PCAT1', 'PCAT2', 'POU5F1B', 'PRNCR1', 'PVT1', 'SNORD74B', 'ST3GAL1', 'TMEM75', 'USP25', 'ZFAT', 'ZFAT-AS1']

Predicted Features

Class Amplicon Complexity Score
Complex non-cyclic 1 1.84267113
Image 1

Class Amplicon Complexity Score
Linear amplification 2 0.1833347834
Image 2

Class Amplicon Complexity Score
ecDNA 3 0.377162753
Image 3

Class Amplicon Complexity Score
BFB 3 1.558481965
Image 4

Class Amplicon Complexity Score
ecDNA 4 0.5844876818
Image 5

Class Amplicon Complexity Score
ecDNA 4 0.9535593801
Image 6

Class Amplicon Complexity Score
Linear amplification 5 0.9925451708
Image 7

Class Amplicon Complexity Score
Complex non-cyclic 6 1.437737396
Image 8

Class Amplicon Complexity Score
Linear amplification 7 1.057967454
Image 9

Class Amplicon Complexity Score
Linear amplification 8 0.7019987616
Image 10

Prediction

ecDNA: negative


Prediction

No data