EKVX_LUNG


Available Data

  • ecDNA Presence Verification from Literature
  • Amplicon Architect Prediction

ID Value
ATCC None
DSMZ None
Cellosaurus None
Cosmic 905970.0

Details

ecDNA Present (Y/N/P): N

Literature source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058031/
https://www.nature.com/articles/nature21356
https://www.nature.com/articles/s41588-020-0678-2

HSR Classification: No data

ATCC Karyotype: No data

DSMZ Karyotype: No data

Heterogeneity Indications and Other Notes: FISH analysis allowed to define that YAP1 copy amplification is contained in a homogeneously staining region in Ca-Ski cell line or as multiple interspersed copies (double minutes) in RO82 and in EKVX cell lines (Figure ​(Figure1b).1b). YAP1 amplification correlated with protein overexpression as detected by western blot analysis. In fact, Ca-Ski, RO82 and EKVX cell lines show high protein level of both total- and phospho(S127)- YAP1, compared to other cancer cell lines lacking 11q22 amplification (Figure ​(Figure1c).1c).

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Prediction

ecDNA Amplicon Predicted: N

Predicted Amplicon Classes: ['Linear amplification']

Predicted Genes on ecDNA

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Predicted Features

Class Amplicon Complexity Score
Linear amplification 1 0.4071512616
Image 1

Class Amplicon Complexity Score
Linear amplification 2 1.205502386
Image 2

Class Amplicon Complexity Score
Linear amplification 3 0.9852585238
Image 3

Class Amplicon Complexity Score
Linear amplification 4 0.4765717743
Image 4

Class Amplicon Complexity Score
Linear amplification 5 1.078927751
Image 5

Class Amplicon Complexity Score
Linear amplification 6 0.5132020048
Image 6

Class Amplicon Complexity Score
Linear amplification 7 1.507384747
Image 7

Class Amplicon Complexity Score
Linear amplification 8 0.6292154517
Image 8

Class Amplicon Complexity Score
Linear amplification 9 0.4330814021
Image 9

Prediction

ecDNA: None


Prediction

No data