Available Data

ecDNA Presence Verification from Literature
Amplicon Architect Prediction
Shatterseek Prediction

ID	Value
ATCC	CRL-2066
DSMZ	None
Cellosaurus	DMS 114
Cosmic	687983.0

Details

ecDNA Present (Y/N/P): Y

Literature source: https://pubmed.ncbi.nlm.nih.gov/6095990/
https://aacrjournals.org/cancerdiscovery/article/13/4/928/725029/Extrachromosomal-DNA-Amplification-Contributes-to

HSR Classification: No data

ATCC Karyotype: No data

DSMZ Karyotype: No data

Heterogeneity Indications and Other Notes: This bimodal line had n u m e r o u s aberrations, i n c l u d i n g minutes, dicen-

Download Breakpoint Edges CSV

Prediction

ecDNA Amplicon Predicted: Y

Predicted Amplicon Classes: ['BFB', 'Linear amplification', 'ecDNA', 'Complex non-cyclic']

Predicted Genes on ecDNA

['PDGFC', 'ACY3', 'ADAM18', 'ADAM2', 'ADAM32', 'ADAM5', 'ADAM9', 'ADGRA2', 'ADRB3', 'AIP', 'ALDH3B1', 'ALDH3B2', 'ANKRD13D', 'ANO1', 'ASH2L', 'BAG4', 'BRF2', 'C11orf24', 'C11orf72', 'C8orf86', 'CABP2', 'CABP4', 'CARNS1', 'CCND1', 'CDK2AP2', 'CHKA', 'CLCF1', 'CORO1B', 'CPT1A', 'CTTN', 'DDHD2', 'DOC2GP', 'EIF4EBP1', 'ERLIN2', 'FADD', 'FAM86C2P', 'FGF19', 'FGF3', 'FGF4', 'FGFR1', 'GAL', 'GOT1L1', 'GPR152', 'GRK2', 'GSTP1', 'HTRA4', 'IDO1', 'IDO2', 'IGHMBP2', 'KDM2A', 'KMT5B', 'LETM2', 'LRP5', 'LSM1', 'LTO1', 'MRGPRD', 'MRGPRF', 'MRGPRF-AS1', 'MRPL21', 'MYEOV', 'NDUFS8', 'NDUFV1', 'NSD3', 'NUDT8', 'PITPNM1', 'PLEKHA2', 'PLPBP', 'PLPP5', 'POLD4', 'PPFIA1', 'PPP1CA', 'PPP6R3', 'PTPRCAP', 'RAB11FIP1', 'RAD9A', 'RHOD', 'RNF5P1', 'RPS6KB2', 'SIRLNT', 'SMIM38', 'SNORD38D', 'SSH3', 'STAR', 'TACC1', 'TBC1D10C', 'TBX10', 'TCIM', 'TCIRG1', 'TESMIN', 'TM2D2', 'TMEM134', 'TPCN2', 'UNC5D', 'UNC93B1']

Predicted Features

View Feature 1 - DMS114_LUNG BFB

Class	Amplicon	Complexity Score
BFB	1	1.726018005

View Feature 2 - DMS114_LUNG Linear amplification

Class	Amplicon	Complexity Score
Linear amplification	2	0.256835547

View Feature 3 - DMS114_LUNG ecDNA

Class	Amplicon	Complexity Score
ecDNA	3	0.7506976955

View Feature 4 - DMS114_LUNG Complex non-cyclic

Class	Amplicon	Complexity Score
Complex non-cyclic	4	0.6897025211

View Feature 5 - DMS114_LUNG ecDNA

Class	Amplicon	Complexity Score
ecDNA	5	1.053559202

View Feature 6 - DMS114_LUNG Linear amplification

Class	Amplicon	Complexity Score
Linear amplification	6	1.004347086

Prediction

ecDNA: None

Prediction

Shatterseek Prediction: No Chromothripsis Detected

Shatterseek High Confidence Chromosomes: None

Shatterseek Low Confidence Chromosomes: None