| Property | Value |
|---|---|
| % Polyploidy | 8.0 |
| Ploidy Classification | hypotriploid |
| Modal Chromosome Number | 65.0 |
| Modal Range Numeric | 59-66 |
| Marker Chromosomes Average Field | 5.0 |
| Primary or Metastasis | Primary |
| Count of SV's | 4 |
ecDNA Present (Y/N/P): N
Literature source:
https://www.nature.com/articles/nature21356
HSR Classification: N
ATCC Karyotype: This is a hypotriploid human cell line with the modal chromosome number of 66, occurring in 24% of cells. Cells with 64 (22%), 65, and 67 chromosome counts also occurred at relatively high frequencies; the rate with higher ploidies was low at 0.4%. There were 6 markers present in single copies in all cells. They include der(6)t(1;6) (q11;q27); ?del(6) (p23); del(11) (q21), del(2) (q11), M4 and M5. Most cells had two X and two Y chromosomes. However, one or both Y chromosomes were lost in 40% of 50 cells analyzed. Chromosomes N2 and N6 had single copies per cell; and N12 and N17 usually had 4 copies. Note: Cytogenetic information is based on initial seed stock at ATCC. Cytogenetic instability has been reported in the literature for some cell lines.
DSMZ Karyotype: human hypotriploid karyotype with 8% polyploidy - 65(59-66)<3n>XXY, -1, -3, -6, +12, -13, -15, -18, -19, -21, -22, +4mar, der(6)t(1;6)(q11;q27), del(11)(q22-23) - presence of large distinctive der(6) marker confirms identity of this cell line
Heterogeneity Indications and Other Notes: No data
ecDNA Amplicon Predicted: N
Predicted Amplicon Classes: []
No features detected.
ecDNA: negative
Shatterseek Prediction: Low Confidence
Shatterseek High Confidence Chromosomes: None
Shatterseek Low Confidence Chromosomes: 2, 3