8305C_THYROID


Available Data

  • Vendor Karyotype
  • ecDNA Presence Verification from Literature
  • Amplicon Architect Prediction
  • Shatterseek Prediction

ID Value
ATCC None
DSMZ ACC-133
Cellosaurus None
Cosmic 906795.0

Property Value
% Polyploidy 22.0
Ploidy Classification hypertriploid
Modal Chromosome Number 74.0
Modal Range Numeric 67-76
Marker Chromosomes Average Field 4.0
Primary or Metastasis Primary
Count of SV's 8

Details

ecDNA Present (Y/N/P): Y

Literature source: https://pubmed.ncbi.nlm.nih.gov/16924234/

HSR Classification: N

ATCC Karyotype: No data

DSMZ Karyotype: human flat-moded hypertriploid karyotype with 22% polyploidy - 74(67-76)<3n>XXX, -2, +9, -10, -12, -13, +14, +15, +15, +18, -19, +20, +4mar, 1-20 dm in most cells, der(6)t(6;7)(q22;q36q11.23), add(15)(p11)x2, del(17)(p12)x2 - subclonal rearrangements, e.g. del(2)(p16), del(2)(q22), del(3)(q22), i(4p), t(6p;7q), del(9)(p23)

Heterogeneity Indications and Other Notes: The 8305C cells showed remarkable amplification with a double-minute chromosome (dmin) pattern. In 8305C cells, RP11-318N1 produced the highest number of signals with a pattern of double-minute chromosomes

Download Breakpoint Edges CSV

Prediction

ecDNA Amplicon Predicted: Y

Predicted Amplicon Classes: ['ecDNA']

Predicted Genes on ecDNA

['AHCY', 'DUSP26', 'DYNLRB1', 'FUT10', 'ITCH', 'MAK16', 'MAP1LC3A', 'PIGU', 'RNF122', 'SNORD13', 'TTI2']

Predicted Features

Class Amplicon Complexity Score
ecDNA 1 0.2390445888
Image 1

Prediction

ecDNA: None


Prediction

Shatterseek Prediction: Low Confidence

Shatterseek High Confidence Chromosomes: None

Shatterseek Low Confidence Chromosomes: 1